Sex-specific associations of prenatal multiple pesticides exposure and early childhood neurodevelopment: Evidence from SMBCS in China
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View abstract on PubMed
Summary
This summary is machine-generated.Prenatal exposure to multiple pesticides, including organophosphates and pyrethroids, may negatively impact early neurodevelopment. Boys appear more susceptible to these adverse effects, highlighting the need for further research and protective measures.
Area Of Science
- Environmental Health
- Neurodevelopmental Toxicology
- Epidemiology
Background
- Prenatal pesticide exposure is a potential risk factor for neurodevelopmental issues.
- Limited research exists on the combined effects of multiple pesticide exposures on long-term neurodevelopment.
Purpose Of The Study
- To investigate the individual and combined impacts of prenatal exposure to various pesticides on neurodevelopmental trajectories.
- To identify specific pesticide groups and metabolites associated with altered neurodevelopmental pathways.
Main Methods
- Latent class trajectory modeling (LCTM) was used to identify neurodevelopmental trajectories in 675 mother-child pairs.
- Urinary concentrations of 25 pesticides and metabolites from five groups (organophosphate, organochlorine, pyrethroid, neonicotinoid, carbamate) were measured.
- Logistic regression and Bayesian kernel machine regression explored associations between pesticide exposure and neurodevelopmental trajectories, with sex-stratified analyses.
Main Results
- Organophosphate, organochlorine, pyrethroid, and carbamate metabolites were prevalent (>90%) in maternal urine.
- LCTM identified a low-score neurodevelopment trajectory group (6.37%) and a high-score group (93.63%).
- Increased urinary cis- and trans-DCCA concentrations were linked to higher odds of the low-score trajectory. Pyrethroid exposure and trans-DCCA were key factors in combined effects, particularly in boys.
Conclusions
- Prenatal exposure to multiple pesticides may impair early-life neurodevelopment.
- Boys exhibit greater susceptibility to the neurodevelopmental effects of prenatal pesticide exposure.
- Findings underscore the importance of evaluating combined pesticide exposures and sex-specific risks.
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