Comprehensive strategy of sonodynamic therapy and gas therapy on tumor treatment

Area of Science:

• Oncology
• Biomedical Engineering
• Nanotechnology

Background:

• Sonodynamic therapy (SDT) is a non-invasive cancer treatment with limited efficacy as a standalone therapy.
• Gas therapy, utilizing specific gas molecules, presents an emerging strategy for direct or indirect tumor cell inhibition.
• Combining therapeutic modalities is crucial for enhancing anti-tumor efficacy and precision.

Purpose of the Study:

• To systematically review the rationales, methodologies, and outcomes of combining sonodynamic therapy and gas therapy for malignant tumors.
• To explore the synergistic interactions between SDT and gas therapy in tumor treatment.
• To assess the potential of combined SDT and gas therapy to improve the tumor microenvironment and reduce side effects.

Main Methods:

• Systematic literature review of studies investigating combined sonodynamic therapy and gas therapy.
• Analysis of mechanisms underlying the synergistic effects, including ultrasound-induced cavitation and gas molecule interactions.
• Evaluation of outcomes related to anti-tumor efficacy, therapeutic precision, safety, and tumor microenvironment modulation.

Main Results:

• A significant synergistic effect exists between sonodynamic therapy and gas therapy in tumor treatment.
• Ultrasound-induced cavitation enhances gas delivery and gas molecules sensitize SDT reactions, ameliorating tumor hypoxia.
• Combined strategies significantly enhance anti-tumor efficacy, improve therapeutic precision and safety, and positively modulate the tumor microenvironment.

Conclusions:

• The combination of sonodynamic therapy and gas therapy presents a promising strategy for enhanced malignant tumor treatment.
• This combinatorial approach offers improved therapeutic precision, safety, and tumor microenvironment modulation.
• The combined treatment strategy demonstrates broad clinical application potential with reduced side effects.