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Related Experiment Video

Updated: Jan 13, 2026

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Exploring Fecal Microbiota Transplantation: Potential Benefits, Associated Risks, and Challenges in Cancer Treatment.

Aswathi Ramesh1, Rajasekaran Subbarayan1,2, Rupendra Shrestha3

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Fecal microbiota transplantation (FMT) shows promise in cancer care by enhancing immunotherapy and reducing side effects. Further research is needed to ensure safety and efficacy for widespread clinical use.

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cancerfecal microbiota transplantationgut microbiomeimmunotherapyoncogenic microbes

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Area of Science:

  • Oncology
  • Microbiome Research
  • Immunotherapy

Background:

  • Fecal microbiota transplantation (FMT) is a novel approach to modulate the gut microbiome.
  • FMT shows potential in improving cancer treatment outcomes and managing complications.

Purpose of the Study:

  • To review the current evidence on FMT's role in oncology.
  • To explore FMT's potential in enhancing immunotherapy and restoring microbiome balance.

Main Methods:

  • Synthesis of preclinical and clinical studies on FMT in cancer treatment.
  • Analysis of FMT's impact on tumor microenvironment and immune responses.

Main Results:

  • FMT can reprogram the tumor microenvironment and improve responses to immune checkpoint inhibitors.
  • FMT may reduce chemotherapy-induced toxicity but carries risks like pathogen transmission and immune dysregulation.
  • Challenges include standardization, regulatory hurdles, and a need for mechanistic understanding.

Conclusions:

  • FMT has transformative potential in cancer care, but requires clinical validation and safety assessments.
  • Interdisciplinary collaboration is crucial for integrating FMT into oncological practice.
  • Innovations like precision microbial consortia may address current limitations.