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Updated: Jan 13, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
A novel method for Tn antigen detection based on chemoenzymatic targeted labelling and CuAAC click chemistry
Hongxia Duan1, Lei Liu2,3, Xin Guo1
1MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian, 116024, China. dongmm@dlut.edu.cn.
Abstract:
The Tn antigen is a key tumor-associated antigen and a promising cancer biomarker. However, its low abundance poses great challenges for sensitive detection. We developed a novel approach that integrates B3GNT6-mediated Tn-specific labelling, click chemistry, and chemiluminescence detection to enable quantitative and sensitive analysis of Tn antigen.
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