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CRISPR-Cas13a diagnostics for circulating microbial transcripts in pancreatic cancer.
Muhammad Shahid Mehmood1, Inbsaat Iqbal2, Fatima Hajj3
1Institute of Microbiology, University of Agriculture Faisalabad, Faisalabad, Pakistan.
Annals of Medicine and Surgery (2012)
|January 7, 2026
Summary
This study proposes a novel, low-cost diagnostic tool for pancreatic cancer using CRISPR-Cas13a technology and microbial RNA biomarkers. This rapid liquid biopsy offers high accuracy for early pancreatic ductal adenocarcinoma detection.
Area of Science:
- Oncology
- Microbiome Science
- Molecular Diagnostics
Background:
- Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with most cases diagnosed at advanced stages.
- Current biomarkers like CA19-9 lack sufficient diagnostic accuracy for early detection.
- There is a critical need for precise, minimally invasive diagnostic tools for PDAC.
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