Mepitel Film or StrataXRT for postmastectomy radiation dermatitis: current evidence and implications

Acute radiation dermatitis (ARD) is a frequent adverse effect following postmastectomy radiotherapy. Barrier dressings such as Mepitel Film and StrataXRT are increasingly used to prevent or reduce its severity, yet comparative data remain limited. Recent studies, mostly single-center or intra-patient in design with small sample sizes, have demonstrated the effectiveness of both in protection against skin toxicity, although larger multicenter validation is still needed. Within the current evidence base, StrataXRT showed advantages in tolerability, comfort, and application convenience, whereas Mepitel Film use offered slightly greater efficacy against ARD. This letter reviews emerging evidence comparing these two interventions, emphasizing their practical implications for clinical decision-making and future research priorities in ARD prevention.