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Related Experiment Video

Updated: Jan 13, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Microbial metabolites regulating PD-L1 and checkpoint pathways: translational implications.

Muhammad Shahid Mehmood¹, Naseeb Danaf²

¹Institute of Microbiology, University of Agriculture Faisalabad, Faisalabad, Pakistan.

Annals of Medicine and Surgery (2012)

|January 7, 2026

Summary

Microbial metabolites like butyrate can enhance immunotherapy response by regulating PD-L1 expression. Metabolomic profiling shows promise in predicting patient responses to cancer treatments.

Area of Science:

Oncology
Immunology
Microbiome research

Background:

Microbial metabolites influence cancer immunotherapy.
Programmed death ligand-1 (PD-L1) is a key regulator of T-cell activity and immunotherapy response.

Keywords:

PD-L1 regulation bile acids immune checkpoints indole derivatives microbial metabolites microbiome–immunotherapy axis short-chain fatty acids translational oncology

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