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Updated: Jul 2, 2026
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A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
Published on: December 20, 2014
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Ureter reconstruction using a biotube in a canine model: A pilot stud.
Noritaka Maeta1, Rosuke Iwai2, Yohei Mochizuki1
1Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoi-no-oka, Imabari, Ehime 794-8555, Japan.
Journal of Stem Cells & Regenerative Medicine
|January 7, 2026
Summary
This study explored biotubes for ureteral repair in dogs. While biocompatible, further research is needed to improve tissue regeneration for long-term ureteral reconstruction.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Urology
Background:
- Ureteral injuries can cause renal dysfunction.
- Current treatments like ureteral stents and grafts have limitations.
- In-body tissue architecture (iBTA) technology offers a novel approach.
Purpose of the Study:
- To evaluate the biocompatibility of biotubes for ureteral reconstruction.
- To assess the potential of iBTA technology in a canine model.
Main Methods:
- Biotubes were implanted to replace ureteral segments in dogs.
- Ureteral stents were used to maintain urinary flow.
- Histological examination assessed tissue regeneration, vascularization, and inflammation.
Main Results:
- Biotubes showed good biocompatibility with no inflammation.
- Epithelial cell invasion occurred, but muscle tissue migration and angiogenesis were limited.
- Biotubes significantly shortened post-implantation.
Conclusions:
- Biotubes show promise as temporary ureteral substitutes.
- Enhancements in epithelialization and muscle tissue integration are required for long-term regeneration.
- Further studies are needed to determine clinical utility for ureteral reconstruction.
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