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Related Experiment Video

Updated: Jan 13, 2026

Harmonic Nanoparticles for Regenerative Research
09:23

Harmonic Nanoparticles for Regenerative Research

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Cold Quad-Modal Nanocomplex for Precise and Quantitative In Vivo Stem Cell Tracking.

Ali Shakeri-Zadeh1,2, Chao Wang1,2, Shreyas Kuddannaya1,2

  • 1The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Advanced Functional Materials
|January 7, 2026
PubMed
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Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics.

Theranostics·2024

Researchers developed a novel quad-modal imaging nanocomplex (Albumin-Bismuth-Superparamagnetic iron oxide or ABS) for simultaneous anatomical and cellular imaging. This advancement aids in evaluating therapeutic efficacy and non-invasively monitoring cell transplantation in vivo.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Current imaging techniques struggle to provide both detailed anatomical context and quantitative cellular data simultaneously.
  • This limitation hinders the precise evaluation and optimization of therapeutic interventions, particularly in cell-based therapies.
  • There is a need for advanced imaging platforms capable of multimodal data acquisition for comprehensive biological assessment.

Purpose of the Study:

  • To develop a versatile, non-radioactive, quad-modal imaging nanocomplex for simultaneous anatomical and cellular visualization.
  • To engineer a single nanoplatform integrating magnetic resonance imaging (MRI), magnetic particle imaging (MPI), computed tomography (CT), and multispectral optoacoustic tomography (MSOT).
  • To demonstrate the utility of this nanocomplex for in vivo cell tracking and monitoring of transplanted cells.
Keywords:
cold nanocomplexmultimodal imagingnon-invasive imagingquantitative cell trackingstem cell labeling

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Related Experiment Videos

Last Updated: Jan 13, 2026

Harmonic Nanoparticles for Regenerative Research
09:23

Harmonic Nanoparticles for Regenerative Research

Published on: May 1, 2014

12.1K
Tracking Mouse Bone Marrow Monocytes In Vivo
12:08

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

10.0K
Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging
09:06

Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging

Published on: March 31, 2008

10.3K

Main Methods:

  • A novel nanocomplex, Albumin-Bismuth-Superparamagnetic iron oxide (ABS), was chemically engineered using bovine serum albumin, superparamagnetic iron oxide, and bismuth sulfide.
  • The ABS nanocomplex was characterized for its multimodal imaging capabilities (MRI, MPI, CT, MSOT).
  • In vivo studies were conducted to assess the high-resolution, real-time imaging of transplanted mesenchymal stem cells in a mouse brain model.

Main Results:

  • The developed ABS nanocomplex successfully enabled simultaneous imaging across four modalities (MRI, MPI, CT, MSOT) within a single nanoplatform.
  • High-resolution, real-time, and quantitative in vivo imaging of transplanted mesenchymal stem cells in the mouse brain was achieved.
  • The study demonstrated the feasibility of using this nanocomplex for tracking and monitoring cell transplantation.

Conclusions:

  • The developed cold (non-radioactive) quad-modal imaging nanocomplex offers a versatile platform for comprehensive in vivo assessment.
  • This technology provides a powerful tool for non-invasive monitoring of cell transfer and transplantation across multiple imaging approaches.
  • The ABS nanocomplex holds significant potential for advancing cell therapy evaluation and other biomedical research applications.