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Association Between TSH Level and Stroke Severity: A Cross-Sectional Study Using the mRS
Afshin Moradi1, Asal Ebrahimian1, Seyed Ardalan Alhoseini1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran, tbzmed.ac.ir.
Insights
Thyroid-stimulating hormone (TSH) levels showed a significant correlation with stroke severity during hospital admission and at discharge. This suggests a potential link between thyroid function and stroke outcomes, warranting further investigation.
Area of Science:
- Neurology
- Endocrinology
- Cardiology
Background:
- Stroke is a leading global health concern, with cardiovascular disease as a primary risk factor.
- Thyroid dysfunction, including thyroid-stimulating hormone (TSH) imbalances, is linked to cardiovascular disease and potentially stroke.
- Investigating the relationship between TSH levels and stroke severity is crucial for understanding disease mechanisms and outcomes.
Purpose of the Study:
- To examine the correlation between thyroid-stimulating hormone (TSH) levels and the severity of stroke.
- To assess how TSH levels relate to stroke disability at different time points.
Main Methods:
- A cross-sectional study involving 204 stroke patients was conducted.
- TSH levels and stroke severity, measured by the modified Rankin scale (mRS), were analyzed.
- Data included patient demographics, comorbidities, TSH levels, stroke subtype, and mRS scores.
Main Results:
- A weak to moderate, statistically significant negative correlation was found between mRS and TSH levels during admission (R = -0.25) and at discharge (R = -0.28).
- No significant correlation was observed before admission or 3 months post-discharge.
- No significant differences in age, gender, stroke type, or CT findings were noted among different TSH level groups.
Conclusions:
- Elevated TSH levels may be associated with less severe stroke symptoms upon admission and discharge.
- Further research with larger cohorts is needed to elucidate the complex relationship between thyroid function and stroke.
Background:
Stroke is a major global health issue with numerous contributing risk factors. One of the most important risk factors of stroke is cardiovascular disease. Other risk factors include dyslipidemia, obesity, diabetes, and thyroid dysfunction which are known to increase the risk of cardiovascular disease. As dysfunction of the thyroid and its related hormones such as thyroid-stimulating hormone (TSH) are in correlation with cardiovascular disease, which may lead to stroke, investigating the correlation between TSH levels and the severity of stroke is worth attention.
Methods:
This cross-sectional study was conducted in Imam Reza Hospital in Tabriz, Iran, from March 2021 to March 2023. In this study, 204 stroke patients whose TSH levels were evaluated were included. Data on age, gender, comorbidities, TSH levels, stroke subtype, and disability severity (measured by the modified Rankin scale [mRS] before admission, during admission, at discharge, and after 3 months) were analyzed using SPSS Version 22.
Results:
Out of 204 patients, TSH levels of 35 (17.2%) patients were below the range (TSH < 0.39), 154 (75.5%) patients within the range (TSH: 0.39-6.19), and 15 (7.4%) patients had TSH levels above the range (TSH > 6.19). There is a weak to moderate but statistically significant correlation between mRS and TSH level during admission (R = -0.25, p < 0.01) and at discharge (R = -0.28, p < 0.01). However, there is a nonsignificant correlation before admission (R = -0.10, p = 0.174) and 3 months after discharge (R = -0.12, p = 0.137). There is not a significant difference among TSH groups comparing their age, gender, type of stroke, and CT scan findings.
Conclusion:
Elevated TSH levels may be associated with less severe stroke symptoms at both admission and discharge. Further studies with larger sample sizes are necessary to better understand the relationship between thyroid function and stroke.
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