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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Related Experiment Video

Updated: Jan 13, 2026

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
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Genome-Wide Association Studies Data and Transcriptomics Data Link Herpes Simplex Virus 1 Infection and Parkinson's

Changhao Lu1,2, Xinyi Cai3, Elena Simula1

  • 1Department of Biomedical Sciences, University of Sassari, Sassari, Italy, uniss.it.

Parkinson'S Disease
|January 7, 2026
PubMed
Summary

Herpes simplex virus 1 (HSV-1) infection is linked to Parkinson's disease (PD). Shared molecular pathways, including neuroinflammation and stem cell changes, offer targets for potential drug repurposing.

Keywords:
Parkinson’s diseaseherpes simplex virus 1herpesviral keratitisnalfurafineneuroinflammation

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Related Experiment Videos

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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Area of Science:

  • Neuroscience
  • Genetics
  • Infectious Diseases

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder with complex etiology.
  • Herpes simplex virus 1 (HSV-1) is a common pathogen with suspected links to neurological conditions.

Purpose of the Study:

  • Investigate the potential causal link between HSV-1 infection and PD using genetic data.
  • Identify shared molecular signatures between HSV-1 infection and PD for mechanistic insights.
  • Explore drug repurposing opportunities based on common molecular pathways.

Main Methods:

  • Utilized summary-level Genome-Wide Association Studies (GWAS) data for causal inference between herpes keratitis (HSV-1) and PD.
  • Analyzed transcriptomics data to identify shared molecular signatures between HSV-1 infection and PD.
  • Performed gene set enrichment analysis to understand the biological functions of shared molecular signatures.

Main Results:

  • Causal inference analysis suggested a relationship between HSV-1 infection and PD.
  • Upregulated shared genes were enriched in neuroinflammation pathways.
  • Downregulated shared genes were enriched in stem cell maintenance and cellular metabolism pathways.

Conclusions:

  • HSV-1 infection is associated with Parkinson's disease.
  • Neuroinflammation and stem cell-related pathways represent shared molecular signatures.
  • These shared pathways present potential targets for drug repurposing, with nalfurafine identified as a candidate.