Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes

Weijia Zhong1, Carlo Scialò1, Beatrice Gatta1

  • 1Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.

Summary

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) pathology is driven by TMEM106B, a lysosomal protein. Lysosomal injury promotes TDP-43 aggregation and cell dysfunction, offering new therapeutic targets.

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