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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

278
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
278
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Psoriasis and atrial fibrillation: Exploring the intersection.

Hitaishi Mehta1, Smriti Gupta2, Juniali Hatwal3

  • 1Department of Dermatology, Sohana Hospital, Mohali, Punjab 140308, India.

World Journal of Experimental Medicine
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Psoriasis patients face a higher risk of atrial fibrillation (AF) due to shared inflammatory pathways. Understanding this link is crucial for integrated dermatological and cardiology care to improve patient outcomes.

Keywords:
Atrial fibrillationBiologic therapiesCardiovascular diseaseCytokinesInflammationPsoriasis

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Area of Science:

  • Cardiology
  • Dermatology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory disease linked to increased cardiovascular risk.
  • Systemic inflammation in psoriasis involves cytokines like IL-6, IL-17, and TNF-alpha.
  • These cytokines may contribute to atrial remodeling and dysfunction, increasing AF susceptibility.

Purpose of the Study:

  • To explore the connection between psoriasis and atrial fibrillation (AF).
  • To review shared inflammatory mechanisms, clinical implications, and research gaps.
  • To highlight the need for integrated care for psoriasis patients at risk of AF.

Main Methods:

  • Review of existing epidemiological and biological data.
  • Synthesis of information on inflammatory mediators and their effects on the atria.
  • Analysis of observational studies and identification of research limitations.

Main Results:

  • Psoriasis is associated with elevated pro-inflammatory cytokines.
  • These cytokines can lead to atrial remodeling, fibrosis, and conduction abnormalities.
  • Severe psoriasis correlates with increased atrial dysfunction and AF risk.

Conclusions:

  • Shared inflammatory mechanisms link psoriasis and AF.
  • Observational studies suggest a causal link, but further research is needed.
  • Integrated dermatological and cardiology care is essential for managing AF risk in psoriasis patients.