Related Experiment Video
Updated: Jan 13, 2026

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Silicosis Diagnosed Using Transbronchial Lung Biopsy: The Pivotal Role of Occupational History
Boon Hau Ng1, Nor Safiqah Sharil2, Hsueh Jing Low3
1Respiratory Unit, Department of Medicine, Faculty of Medicine Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz Kuala Lumpur Malaysia.
Abstract:
Pulmonary silicosis, a preventable occupational lung disease caused by chronic inhalation of crystalline silica dust in industries like construction, mining, and stone masonry, remains underdiagnosed in TB-endemic regions due to overlapping clinical and radiological features. A 63-year-old man presented with upper gastrointestinal bleeding, but a silent lung abnormality stole the clinical spotlight. In a TB-endemic setting, incidental reticulonodular opacities triggered a full tuberculosis work-up, even in the absence of cough or respiratory symptoms. Yet it was only after a delayed occupational history revealed three decades of unprotected mosaic tiling that silicosis was considered. High-resolution CT and transbronchial lung biopsy later confirmed the diagnosis, but not before the patient's course was complicated by obstructive uropathy and sepsis. This case highlights the diagnostic pitfalls of radiologic overlap between silicosis and tuberculosis, as well as the crucial role of occupational exposure history in reaching the correct diagnosis.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...

