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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
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Metabolic Alterations Associated With Diet and Hypertension in Rats.
Kristina Smoradkova1, Mateusz Szudzik2, Klaudia Maksymiuk2
1Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava, 845 05, Slovakia, sav.sk.
Journal of Nutrition and Metabolism
|January 7, 2026
Summary
Unhealthy diets and hypertension alter amino acid levels in tissues. High-fat diets increase methylglycines, while high salt and hypertension reduce them, impacting cardiometabolic disease risk.
Area of Science:
- Biochemistry
- Metabolomics
- Cardiovascular Research
Background:
- Unhealthy diet and hypertension are key risk factors for cardiometabolic diseases.
- The precise impact of diet and blood pressure on metabolic profiles is not fully understood.
Purpose of the Study:
- To investigate the effects of diet and hypertension on amino acid and nutrient profiles.
- To identify metabolic alterations in various animal models of disease.
Main Methods:
- Utilized liquid chromatography and mass spectrometry.
- Analyzed plasma and tissue samples from animal models with high-fat, high-disaccharide, high-salt diets, and hypertension.
Main Results:
- High-fat diet elevated tissue methylglycines (betaine, sarcosine) and glycine.
- High salt intake and hypertension reduced methylglycine species and increased taurine.
- Observed tissue-specific changes in alanine and beta-alanine concentrations.
Conclusions:
- Diet and hypertension induce distinct metabolic changes in amino acid profiles.
- Findings provide insights into metabolic alterations linked to cardiometabolic disease development.
- Further research is needed to clarify the implications of these metabolic shifts.
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