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Circulating MALAT1 in Preeclampsia and Association With Cardiometabolic Risk.

Tove Lekva1, Monica Frøystad1,2, Annika E Michelsen1,2

  • 1Research Institute of Internal Medicine (T.L., M.F., A.E.M., Y.K., P.A., B.H., T.U.), Oslo University Hospital, Rikshospitalet, Norway.

Hypertension (Dallas, Tex. : 1979)
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Preeclampsia is linked to lower levels of MALAT1 RNA in pregnant women. These decreased MALAT1 and NEAT1 levels persist after pregnancy and are associated with cardiovascular disease risk.

Keywords:
cardiovascular diseasesendothelial cellsleukocytes, mononuclearmacrophagespre-eclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Disease Research
  • Molecular Biology

Background:

  • Preeclampsia affects 2-8% of pregnancies and increases cardiovascular disease risk in women with a history of the condition.
  • The long noncoding RNA MALAT1 regulates inflammatory responses associated with cardiovascular disease.
  • MALAT1 levels are decreased in preeclampsia placentas and may influence nearby RNA expression.

Purpose of the Study:

  • To investigate the expression of MALAT1, NEAT1, mascRNA, SCYL1, and FRMD8 in women with and without preeclampsia.
  • To assess the association of these RNAs with cardiometabolic risk markers in women with a history of preeclampsia.
  • To explore the functional role of MALAT1 in inflammatory responses relevant to preeclampsia and cardiovascular disease.

Main Methods:

  • Assessed expression of MALAT1, NEAT1, mascRNA, SCYL1, and FRMD8 in peripheral blood mononuclear cells and plasma/extracellular vesicles.
  • Collected samples from healthy and preeclampsia women during pregnancy (STORK cohort) and at 5-year follow-up.
  • Performed in vitro silencing of MALAT1 in differentiated macrophages to assess its effect on inflammatory markers.

Main Results:

  • MALAT1, NEAT1, mascRNA, and FRMD8 were decreased in peripheral blood mononuclear cells during preeclampsia.
  • In women with a preeclampsia history, follow-up levels of MALAT1 and NEAT1 in peripheral blood mononuclear cells were decreased and associated with cardiometabolic markers.
  • Silencing MALAT1 in macrophages increased IL-6 secretion and reduced MMP9 and VEGF-A levels.

Conclusions:

  • Decreased MALAT1 and NEAT1 in peripheral blood mononuclear cells are associated with preeclampsia during pregnancy and at follow-up.
  • These RNA transcripts show associations with cardiometabolic risk markers in women with a history of preeclampsia.
  • MALAT1 and neighboring RNAs may serve as potential therapeutic targets for managing preeclampsia and associated cardiometabolic risks.