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When light passes through a substance, a portion of the light is absorbed while the remaining light is reflected or transmitted. If the molecule absorbs light between the wavelengths of 180–400 nm range, the UV spectrum is obtained, and if it absorbs light in the 400–780 nm wavelength range, the visible spectrum is obtained.     
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Updated: Jan 13, 2026

Minimal Erythema Dose MED Testing
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Narrowband ultraviolet B minimal erythema dose reference range.

Ewan Eadie1, Brian Todd1, Sanchez Luzvminda2

  • 1NHS Tayside, Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK.

Clinical and Experimental Dermatology
|January 7, 2026
PubMed
Summary

Minimal erythema dose (MED) testing for narrowband ultraviolet-B (NB-UVB) phototherapy shows variation by skin type and location. Updated MED ranges are needed, especially for darker skin types, to optimize treatment.

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Area of Science:

  • Dermatology
  • Photobiology
  • Clinical Research

Background:

  • Narrowband ultraviolet-B (NB-UVB) phototherapy is a standard treatment for skin conditions.
  • Minimal erythema dose (MED) testing is crucial for determining optimal NB-UVB dosage and identifying photosensitivity.
  • Variability in MED values can impact treatment efficacy and safety.

Purpose of the Study:

  • To analyze and compare Minimal Erythema Dose (MED) values from two distinct patient cohorts undergoing narrowband ultraviolet-B (NB-UVB) phototherapy.
  • To investigate the relationship between MED values and Fitzpatrick Skin Phototype (SPT).
  • To establish updated reference ranges for NB-UVB MED testing and inform clinical practice.

Main Methods:

  • Retrospective analysis of MED values from 882 patients in Dundee and 188 in London.
  • Exclusion of patients with abnormal photosensitivity or repeat MED tests.
  • Statistical comparison of MED values across different Fitzpatrick Skin Phototypes (SPT) and between the two study centers.

Main Results:

  • Median MED values generally increased with higher Fitzpatrick Skin Phototypes (SPT), but significant overlap was observed.
  • Dundee cohort showed statistically lower MED values compared to the London cohort for SPT II/III.
  • Lower MEDs were reported compared to previous volunteer studies, with higher non-responder rates in SPT IV-VI.

Conclusions:

  • Existing MED values for NB-UVB phototherapy exhibit inter-center variability and require updated reference ranges.
  • Current testing protocols may need adjustment, particularly for individuals with darker skin types (SPT IV-VI), to address higher non-responder rates.
  • These findings support refining NB-UVB phototherapy protocols for improved patient outcomes.