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Updated: Jan 13, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals
Guillermo Gómez-Tenés1, Alechania Misturini1, Neyvis Almora-Barrios1
1Functional Inorganic Materials Team, Instituto de Ciencia Molecular (ICMol), Universitat de València, Paterna 46980, Spain.
None:
Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without compromising crystallinity. Only the histidine-functionalized material exhibits high enantioselectivity for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing the importance of local pore reorganization in chiral molecular recognition.
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