Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
What is the Immune System?01:38

What is the Immune System?

126.5K
Overview
126.5K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Teeth01:15

Teeth

1.6K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.6K
T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic determinants of drug-induced gingival overgrowth.

Scientific reports·2026
Same author

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.

Journal of periodontology·2025
Same author

Multi-Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome.

Journal of periodontal research·2025
Same author

N-acyl homoserine lactone signaling modulates bacterial community associated with human dental plaque.

NPJ biofilms and microbiomes·2025
Same author

Female Mice Lacking LSD1 in Myeloid Cells Are Resistant to Inflammatory Bone Loss.

Cells·2025
Same author

Accuracy of Metabolomics in Peri-Implant Crevicular Fluid for Diagnosis and Prognosis of Peri-Implantitis.

Journal of periodontal research·2025

Related Experiment Video

Updated: Jan 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.2K

Autoimmunity and Periodontitis.

Massimo Costalonga1, Vivek Thumbigere-Math2, Mark C Herzberg1

  • 1Division of Basic Sciences, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.

Journal of Periodontal Research
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Systemic autoimmunity occurs when immune tolerance fails, leading to self-reactive T and B cells attacking host tissues. Periodontitis exacerbates this by promoting citrullination and epitope spreading, activating dormant autoreactive cells and driving autoimmune diseases.

More Related Videos

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.8K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.8K

Related Experiment Videos

Last Updated: Jan 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.2K
Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

12.8K
Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

19.8K

Area of Science:

  • Immunology
  • Autoimmunity
  • Periodontal disease

Background:

  • Autoimmunity results from the failure of immune tolerance, allowing self-reactive lymphocytes to attack host tissues.
  • Periodontitis involves inflammation and protein modifications that can trigger or worsen autoimmune conditions.

Purpose of the Study:

  • To review the immune mechanisms linking periodontitis to systemic autoimmunity.
  • To explain how periodontal pathobionts contribute to the development and exacerbation of autoimmune diseases.

Main Methods:

  • This narrative review synthesizes current evidence on immune tolerance, T and B cell activation, and post-translational modifications in autoimmunity.
  • It examines the role of periodontal pathogens like Porphyromonas gingivalis in initiating and amplifying autoimmune responses.

Main Results:

  • Dormant autoreactive T cells can be activated by modified self-antigens or microbial peptides during periodontitis.
  • Periodontitis promotes citrullination and epitope spreading, broadening the autoimmune response.
  • Periodontal pathobionts contribute to systemic autoimmunity through molecular mimicry and inflammation.

Conclusions:

  • Periodontitis not only causes local tissue destruction but also systemic autoimmunity.
  • Mechanisms like citrullination and epitope spreading in periodontitis can initiate or exacerbate autoimmune diseases such as rheumatoid arthritis, IBD, and AD.