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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Severe methemoglobinemia in a patient with pneumococcal sepsis]
Sofia Johansson1, Ragnar Henningsson2, Staffan Tevell3
1specialistläkare, Anopiva, Central-sjukhuset Karlstad.
Abstract:
Methemoglobinemia is a condition characterized by tissue hypoxia and normal oxygen partial pressure in the blood. The methemoglobin is created through the oxidation of the hemoglobin molecule in erythrocytes, changing Fe2+ to its ferric state Fe3+, causing it to lose its oxygen-carrying capacity. The condition can be drug-induced, caused by congenital enzyme deficiency or triggered through disease processes such as sepsis. In this case report, we describe an 80-year-old woman who developed severe methemoglobinemia in connection with a fatal pneumococcal sepsis.
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