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Paper-based microfluidics for wearable soft bioelectronics.

Feng Zhang1, Ganggang Zhao2, Qunle Ouyang2

  • 1Department of Chemical and Biomedical Engineering, University of Missouri, Columbia, MO, USA. yanzheng@missouri.edu.

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|January 7, 2026
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Summary
This summary is machine-generated.

Paper-based microfluidics are key for wearable biosensors, enabling continuous health monitoring. This review covers their design, applications in diagnostics, and future potential for personalized healthcare solutions.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Wearable biosensing technologies offer continuous, real-time physiological monitoring.
  • Flexible microfluidics, especially paper-based, are crucial interfaces for biofluid handling in wearable devices.
  • These systems enable non-invasive diagnostics at the point of care.

Purpose of the Study:

  • To review the fundamentals of paper-based microfluidics for wearable biosensing.
  • To highlight design considerations, fabrication techniques, and on-skin applications.
  • To discuss challenges and future perspectives for clinical translation.

Main Methods:

  • Review of existing literature on paper-based microfluidics.
  • Analysis of material design, structural regulation, and interface engineering principles.
  • Examination of fabrication methods and on-skin application case studies.

Main Results:

  • Paper-based microfluidics allow precise, capillary-driven biofluid handling for diagnostics.
  • Innovative applications include on-skin sampling, biosensing, and disease detection.
  • Key milestones in device development and fabrication have been achieved.

Conclusions:

  • Paper-based microfluidics are vital for personalized wearable healthcare.
  • Addressing challenges in clinical translation is essential for widespread adoption.
  • Future integration with AI and IoT will drive next-generation healthcare solutions.