Expert Consensus on 5-aminolevulinic Acid Photodynamic Therapy for Oral Potentially Malignant Disorders

Area of Science:

• Oral Medicine
• Oncology
• Photochemistry

Background:

• Oral potentially malignant disorders (OPMDs) require effective, non-invasive treatment options.
• Photodynamic therapy (PDT) utilizing 5-aminolevulinic acid (5-ALA) shows promise for OPMDs.
• Standardized protocols are needed to optimize 5-ALA-PDT efficacy and safety.

Purpose of the Study:

• To provide a comprehensive consensus guide for the clinical application of 5-ALA-PDT in managing OPMDs.
• To standardize treatment protocols, including irradiation parameters and lesion assessment.
• To enhance clinical outcomes and establish a scientific basis for 5-ALA-PDT in oral mucosal diseases.

Main Methods:

• Consensus document development based on current clinical evidence and expert opinion.
• Detailed recommendations covering patient selection, diagnosis, and treatment protocols.
• Guidelines for efficacy evaluation and management of adverse events post-treatment.

Main Results:

• 5-ALA-PDT is a significant non-invasive treatment for OPMDs like oral leucoplakia and erythroplakia.
• The consensus provides detailed recommendations on irradiation dose, time, light source, and pre-treatment preparation.
• Standardized procedures aim to improve clinical outcomes and address challenges in managing oral mucosal diseases.

Conclusions:

• 5-ALA-PDT represents a valuable therapeutic strategy for OPMDs.
• Standardization of 5-ALA-PDT through this consensus will improve treatment consistency and effectiveness.
• This guide supports oral mucosal specialists in optimizing PDT for oral mucosal diseases.