Related Experiment Video
Updated: Jan 13, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Difluoromethylation of Arylsulfonium Salts with TMSCF2H
Jian Yang1, Jia-Wei Song1, Cheng-Pan Zhang1
1School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China.
Abstract:
A catalyst-free difluoromethylation of arylphenothiazinium salts with TMSCF2H in DMF in the presence of CsF is achieved. The reaction proceeded smoothly at room temperature to furnish the corresponding difluoromethylated products in good yield with excellent selectivity through the formation and ligand coupling of sulfurane intermediates. This protocol represents the first catalyst-free difluoromethylation of arylsulfonium salts, exhibiting features distinct from those of previously reported metallophotocatalytic fluoroalkylation.
More Related Videos
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
12:30Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Related Concept Videos
Preparation and Reactions of Sulfides
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Preparation and Reactions of Thiols
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Electrophilic Aromatic Substitution: Sulfonation of Benzene