Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intraoperative Nodule Localization in Non-Small-Cell Lung Cancer: Existing and Emerging Techniques.

Cancers·2026

Same author

Phloiokeratosis is a new ichthyosiform hyperkeratotic cornification disorder in dogs with SUV39H1 variants.

Scientific reports·2026

Same author

The Addition of a 3D Balanced Steady-State Free Precession Pulse Sequence Improves Magnetic Resonance Imaging Identification of Certain Canine Cranial Nerves.

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2026

Same author

Magnetic Resonance Imaging Features of Intravascular Osteosarcoma Affecting the Ventral Internal Vertebral Venous Plexus Causing Cervical Myelopathy in a Dog.

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2026

Same author

3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.

Antioxidants (Basel, Switzerland)·2026

Same author

Near-Infrared Imaging in Small Animal Surgical Oncology: Current Applications and Future Directions.

Animals : an open access journal from MDPI·2026

Same journal

Clinical Validation of a Multiplex Urine Biomarker Assay for Surveillance of Recurrent Bladder Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same journal

Epigenetic Liquid Biopsy Enables Universal Mutation-Agnostic Molecular Surveillance for High-Risk Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same journal

Claudin 18.2 Targeting: A Pan-Cancer Perspective.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same journal

High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same journal

Pediatric Brain Tumor Consortium phase 1 study of CD40 agonist sotigalimab in pediatric and young adult patients with recurrent CNS tumors and newly-diagnosed DIPG.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same journal

A randomized phase 2 study of combination atezolizumab and varlilumab (CDX-1127) with or without cobimetinib in previously-treated unresectable biliary tract cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

Near-Infrared Imaging Using a Cathepsin-Targeted, Quenched Activity-Based Probe Identifies Naturally Occurring Canine

Anna M Massie¹, Charles W Bradley², Wilfried Mai¹

¹Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

|January 7, 2026

Summary

This summary is machine-generated.

A novel cathepsin-targeted probe (VGT-309) shows promise for detecting osteosarcoma in dogs. This imaging tool may help surgeons achieve complete tumor removal during limb-sparing surgery.

More Related Videos

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

Related Experiment Videos

Last Updated: Jan 13, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

Published on: August 14, 2012

Area of Science:

Oncology
Medical Imaging
Translational Research

Background:

Osteosarcoma is the most common primary bone cancer.
Current treatments have not significantly improved survival rates.
Complete tumor excision is crucial for better prognosis.

Purpose of the Study:

To evaluate the safety and feasibility of a cathepsin-targeted activity-based probe (VGT-309) in dogs with osteosarcoma.
To assess the probe's ability to delineate tumor margins.
To explore its potential as an intraoperative tool for limb-sparing surgery.

Main Methods:

Twelve dogs with appendicular osteosarcoma received intravenous VGT-309.
Limb amputation was performed 16-20 hours post-injection.
Fluorescence imaging was compared with MRI and histopathology.

Main Results:

All osteosarcomas fluoresced, correlating with MRI and histopathology.
Fluorescence was visible through cortical bone but didn't always show intramedullary extension.
Necrotic tumor areas did not fluoresce.

Conclusions:

VGT-309 is safe and feasible for assessing canine osteosarcoma extent.
The probe shows potential for intraoperative detection in human limb-sparing surgery.
It is most useful for assessing residual tumor after resection, with caution for necrotic areas.