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Combined Large Cell Neuroendocrine Carcinoma With Enteric-Type Adenocarcinoma of the Lung

Motohiro Tsuchiya¹, Kazuyuki Komori^2,3, Koji Kameda^2,4

¹Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan.

Pathology International

|January 7, 2026

Abstract:

Reported herein is an extremely rare case of combined LCNEC with enteric-type adenocarcinoma of the lung (EAL) in a 72-year-old male. The LCNEC component was further divided into two subcomponents, based on cohesiveness and immunohistochemical characteristics. Overall, the heterogeneity of this tumor demonstrated an unusual histologic pattern of combined LCNEC.

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