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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Light-Driven Upconverting Nanoparticles-Based Nanodevice for Accurate Subcellular Dual Molecular Imaging and
Ruoyan Li1, Huanhuan He1, Jing Feng1
1Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
This study introduces an intelligent nanodevice for precise tumor imaging and therapy. The light-controlled DNAzyme probe enables dual-target visualization and synergistic treatment using upconversion nanoparticles (UCNPs).
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Molecular Imaging
Background:
- Developing nanodevices for precise, simultaneous diagnosis and therapy is challenging.
- Mitochondria-targeted drug delivery and therapy require advanced nanocarriers.
Purpose of the Study:
- To create an intelligent nanodevice for dual-target imaging and synergistic therapy in mitochondria.
- To utilize light-controlled DNAzyme probes for enhanced diagnostic and therapeutic precision.
Main Methods:
- Engineered silica-shelled upconversion nanoparticles (UCNPs) co-delivering photosensitizer (Ce6) and DOX.
- Integrated DNAzyme probes for sequential imaging of miRNA-21 and APE1.
- Mitochondria-targeting via triphenylphosphonium for targeted therapy.
Main Results:
- Achieved specific imaging of tumors with high spatiotemporal precision.
- Demonstrated enhanced synergistic therapy efficacy through combined DOX release and photodynamic therapy.
- Validated the nanodevice's function in live biosystems.
Conclusions:
- The developed all-in-one nanodevice offers a promising strategy for integrated cancer diagnosis and therapy.
- Intelligent nanodevices show potential for advancing theranostic applications.
- Light-controlled DNAzyme probes enhance precision in nanomedicine.
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