Related Experiment Video
Updated: Jan 13, 2026
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Effects of a Digital Multidomain Cognitive Intervention in Older People at High Risk of Dementia: A Randomized
Yuanjiao Yan1, Xinying Lin1, Ying Lu2
1The School of Nursing, Fujian Medical University, Fuzhou, China.
Abstract:
Objective: To evaluate the effects of a 6-month digital multidomain cognitive intervention on cognitive function and psychosocial outcomes in older adults at high risk of dementia.
Abstract:
Methods: A 2-arm, randomized clinical trial was conducted at Fujian Provincial Hospital and 4 community health care centers (April 2024 to December 2024). Participants (N=166, aged ≥60 years, modified dementia risk score >79) were enrolled and randomized 1:1 to a 6-month digital multidomain cognitive intervention and control group. Primary outcomes included general cognitive function (Montreal Cognitive Assessment [MoCA]) scores; secondary outcomes covered memory (Rey-Osterrieth Complex Figure Test [ROCFT] and Auditory Verbal Learning Test), language (Verbal Fluency Test and Boston Naming Test), executive function and attention (Shape Trails Test), visuospatial skill (ROCFT), mobility (Activity of Daily Living and Berg Balance Scale), psychosocial status (15-item Geriatric Depression Scale, Zung Self-Rating Anxiety Scale, UCLA Loneliness Scale, and Quality of Life-Alzheimer's Disease), and health-promoting behaviors (Health-Promoting Lifestyle Profile II and Self-Rated Abilities for Health Practices). Intention-to-treat analysis with random forest imputation was performed.
Abstract:
Results: A total of 154 participants (92.77%) completed the trial. Compared to the control group, the intervention group demonstrated significant improvements in general cognitive function, visuospatial memory, and loneliness, including MoCA (t=2.106, P=.037), ROCFT immediate and long-delay recall (Z=-2.789, P=.05; t=2.797, P=.05), and UCLA Loneliness Scale (Z=-2.641, P=.008). No statistically significant between-group differences emerged in other indicators.
Abstract:
Conclusion: A 6-month digital multidomain intervention significantly enhanced general cognitive function and visuospatial memory and reduced loneliness in older adults at high risk for dementia. These results highlight the potential of WeChat-based delivery models to provide feasible, acceptable, and widely applicable solutions for dementia risk reduction in aging populations.
Abstract:
Trial Registration: ClinicalTrials. gov identifier: NCT06442943.
More Related Videos
06:58Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
07:01Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
Related Concept Videos
01:30Cognitive Development During Adulthood
01:22Alzheimer's Disease: Treatment
01:30Dementia
The progression of dementia is generally gradual....
01:26Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age