Characteristics and Predictors of Pediatric and Adult Patients with Inherited Retinal Degenerations: Tertiary Care Ophthalmology Clinic Data
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric patients with inherited retinal degenerations (IRDs) often show refractive and developmental issues, while adults present with progressive vision loss. Understanding these differences in IRD presentation can improve diagnosis and care.
Area Of Science
- Ophthalmology
- Genetics
- Clinical Medicine
Background
- Inherited retinal degenerations (IRDs) are a group of genetic disorders affecting vision.
- These conditions impact various retinal cells, leading to progressive vision impairment.
Purpose Of The Study
- To compare the clinical and demographic characteristics of pediatric and adult patients with IRDs at their first visit.
- To identify distinct features associated with age at presentation for IRDs.
Main Methods
- A retrospective chart review was performed on 527 patients diagnosed with IRDs.
- Data included age, diagnosis, ocular and systemic features, and referral information.
Main Results
- Pediatric IRD patients more commonly had high hyperopia, myopia, astigmatism, syndactyly, and developmental delay.
- Adult IRD patients frequently experienced reduced central/peripheral vision, color deficits, nyctalopia, and cataracts.
- Adults with IRDs had higher rates of cardiac conditions compared to controls.
Conclusions
- Age at presentation for IRDs is associated with distinct clinical and familial characteristics.
- Pediatric IRDs often manifest with refractive and developmental anomalies, whereas adult IRDs present with progressive visual symptoms.
- Understanding these age-related patterns can enhance early recognition and timely treatment of IRDs.
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