Mussel-Inspired Biodegradable Ca²⁺ Complex Double Network Pectin-Based Hydrogel for Hemostasis and Tissue...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Diabetic wounds present challenges like inflammation, oxidative stress, and poor angiogenesis.
• Existing treatments often fail to address these multifactorial issues comprehensively.

Purpose of the Study:

• To develop a multifunctional mussel-inspired double network (DN) hydrogel for enhanced diabetic wound healing.
• To address persistent inflammation, oxidative stress, and impaired angiogenesis in chronic wounds.

Main Methods:

• Fabrication of a catechol- and polyphosphate-modified natural biomacromolecular-based DN hydrogel.
• Evaluation of mechanical adaptability under high-glucose conditions.
• Assessment of hemostatic capacity, ROS scavenging, anti-inflammatory effects, and pro-regenerative signaling.

Main Results:

• The hydrogel demonstrated tailored mechanical adaptability and conformal coverage in simulated wound environments.
• It exhibited inherent hemostatic capacity through rapid adhesion and coagulation activation.
• The hydrogel effectively scavenged reactive oxygen species (ROS), reduced inflammation, and promoted angiogenesis, collagen deposition, and epithelial regeneration.

Conclusions:

• The mussel-inspired glycosyl cyclic hydrogel acts as a multifunctional platform for wound management.
• It integrates microenvironment regulation, dynamic adaptability, and pro-regenerative signaling for refractory diabetic wound healing.
• This hydrogel shows significant potential as a next-generation wound dressing.