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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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Optimizing exercise interventions for depression in stroke patients: A network and dose-response meta-analysis.

Wei Wang1, Zhide Liang2, Jiao Xiong1

  • 1Nursing College, Guangxi University of Chinese Medicine, Guangxi, China.

Journal of Psychosomatic Research
|January 7, 2026
PubMed
Summary

Aerobic exercise is the most effective intervention for post-stroke depression (PSD). The optimal dose range for exercise interventions is 500-1100 METs-min/week for improving depressive symptoms.

Keywords:
Depression in stroke patientsExercise interventionsMeta-analysis

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Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Post-stroke depression (PSD) is a frequent complication following stroke, increasing mortality risk.
  • Exercise demonstrates potential benefits for depression, yet optimal intervention strategies remain undefined.

Purpose of the Study:

  • To determine the optimal exercise intervention modality and dose for managing post-stroke depression.
  • To provide evidence-based recommendations for exercise prescriptions in PSD patients.

Main Methods:

  • A systematic literature search was conducted across six databases for randomized controlled trials (RCTs) up to September 2025.
  • Network meta-analysis (NMA) was performed using a random-effects model to compare different exercise interventions.
  • The Cochrane risk of bias tool assessed the quality of included studies.

Main Results:

  • Twenty-nine RCTs involving 1061 patients were analyzed.
  • Aerobic exercise showed the highest effectiveness (Hedges' g = -1.14), followed by qigong and flexibility exercises.
  • The optimal weekly exercise dose was identified as 500-1100 METs-min/week.

Conclusions:

  • Exercise interventions significantly improve depressive symptoms in post-stroke patients.
  • Exercise can be considered a non-pharmacological adjunct to standard care for PSD.
  • Individualized exercise prescriptions are recommended due to varying effectiveness based on patient characteristics.