Recent advances of biomacromolecules-based functional microcarriers in bone tissue repair: A review
Ruirui Kong1, Liyang Zhang1, Feilong Zhao1
1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 10083, China.
Abstract:
Biomacromolecules-based functional microcarriers, owing to their injectability, good fluidity, and large comparative area, effectively repair various irregular bone defects and have thus become a widely adopted class of scaffold materials in bone tissue engineering. This review systematically examines the diverse fabrication techniques and material compositions of microcarriers, emphasizing the importance of context-specific selection based on clinical requirements. Additionally, it provides an up-to-date synthesis of recent advancements in microcarrier-based applications for bone regeneration. Beyond their role as delivery systems, microcarriers serve dual functions as both cellular supports and bioactive platforms that enhance cell proliferation and osteogenic differentiation. Ultimately, this comprehensive analysis aims to stimulate further innovation and translation of microcarrier technology in regenerative medicine.
More Related Videos
Related Concept Videos
01:40Bone Remodeling
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...