Related Experiment Video
Updated: Jan 13, 2026
08:44
Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes
Published on: July 30, 2020
5.3K
Design of liposomal tocopherol phosphate for dermal applications
Mais M Saleh1, Nowar Alsarayreh2, Nour Aladaileh2
1Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman 11942, Jordan.
International Journal of Pharmaceutics
|January 7, 2026
Summary
Liposomes loaded with tocopherol phosphate (TPLP) show promise for skin hydration and wound healing. These nanolipid carriers enhance skin barrier function and promote cell migration, demonstrating potential in cosmeceutical and therapeutic applications.
Area of Science:
- Dermal drug delivery
- Nanotechnology in cosmetics
- Wound healing research
Background:
- Liposomes are effective nanolipid carriers for cosmeceutical dermal delivery.
- They form a film on the skin, reducing water loss and increasing hydration.
- Tocopherol phosphate (TP) is a valuable active ingredient for skin applications.
Purpose of the Study:
- To assess the feasibility of creating liposomal tocopherol phosphate (TPLP) formulations.
- To evaluate TPLP's skin penetration, hydration, cell migration, and wound healing capabilities.
- To explore TPLP as a cosmeceutical and wound healing agent.
Main Methods:
- TPLP formulations prepared using the thin film hydration method.
- In vitro release testing and ex vivo skin penetration studies in Franz diffusion cells.
- In vitro scratch assay on human dermal fibroblasts and in vivo mouse excisional wound model.
Main Results:
- TPLP-7 formulation exhibited physical stability, small particle size, and low PDI.
- TPLP-7 showed significant skin hydration effects (reduced TEWL) compared to free TP.
- Enhanced human dermal fibroblast migration and accelerated wound closure in vitro and in vivo.
Conclusions:
- Liposomal tocopherol phosphate (TPLP) is a stable and effective formulation for dermal delivery.
- TPLP demonstrates superior skin hydration and antioxidant properties.
- TPLP liposomes show significant potential for cosmeceutical and wound healing applications.
