Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Binet's Contribution to Measures of Intelligence

Binet's Contribution to Measures of Intelligence

Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis.

Prenatal diagnosis·2026

Same author

Multiscale heterogeneity of atypical functional connectivity in autism.

Nature. Mental health·2026

Same author

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease.

JAMA network open·2026

Same author

Stress, coping, protective factors, and quality of life in parents of infants with CHD: associations with state anxiety.

Cardiology in the young·2026

Same author

Spatial analysis of physical activity and ambient air pollution in Kuwait: a cross-sectional study.

Scientific reports·2026

Same author

A tutorial on person ability scores for the IDD clinician.

International journal of developmental disabilities·2026

Search research articles

Related Experiment Video

Updated: Jan 13, 2026

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Published on: March 14, 2018

Developing Meaningful Score Differences for the Bayley-4 and Vineland-3 in Angelman Syndrome Using a Delphi Panel.

Sonya Powers¹, Katherine N Anderson², Wen-Hann Tan²

¹RTI International, Research Triangle Park, NC, USA; Edmentum, Minneapolis, MN, USA.

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research

|January 7, 2026

Summary

Caregivers established meaningful score differences (MSDs) for the Bayley Scales of Infant Development, Fourth Edition (Bayley-4) and Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) in individuals with Angelman syndrome (AS). These MSDs reflect changes impacting daily life and quality of life for AS patients and their families.

Keywords:

Angelman syndrome clinical outcome assessment meaningful change

More Related Videos

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Related Experiment Videos

Last Updated: Jan 13, 2026

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

Published on: March 14, 2018

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Area of Science:

Developmental Psychology
Clinical Assessment
Rare Diseases

Background:

Angelman syndrome (AS) is a rare genetic disorder affecting development.
Standardized assessments like the Bayley Scales of Infant Development, Fourth Edition (Bayley-4) and Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) are used to track development in individuals with AS.
Establishing meaningful score differences (MSDs) is crucial for interpreting assessment results in the context of daily functioning.

Purpose of the Study:

To develop within-patient meaningful score differences (MSDs) for the Bayley-4 and Vineland-3 assessments.
To incorporate the caregiver perspective in defining what constitutes a meaningful change for individuals with Angelman syndrome (AS).

Main Methods:

A Delphi method was employed with a panel of 19 caregivers of individuals with AS.
Caregivers rated vignettes describing varying baseline functioning levels to determine MSDs for Bayley-4 and Vineland-3 subscales.
An iterative process with three rating rounds and two discussion rounds was used to achieve consensus.

Main Results:

High agreement rates (≥70%) were achieved for final MSD ratings across Bayley-4 and Vineland-3 subscales.
MSD thresholds were not fixed cut-offs but varied based on the individual's baseline functioning level.
The study identified preliminary MSD estimates for interpreting changes in individuals with AS.

Conclusions:

The Delphi Panel method effectively integrated caregiver insights to establish preliminary MSDs for the Bayley-4 and Vineland-3 in individuals with AS.
These caregiver-defined MSDs provide a valuable framework for understanding meaningful within-person change in AS, considering diverse baseline functioning levels.