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Updated: Jan 13, 2026

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
Published on: November 3, 2023
[Summary of the best evidence for diaphragmatic function training in mechanically ventilated patients]
Jie Jing1, Xiaowei Chang, Hongbo Luo
1Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Corresponding author: Li Zunzhu,
Objective:
To summarize the best available evidence regarding diaphragmatic function training in mechanically ventilated patients and to establish a foundation for clinical practice.
Methods:
Systematic searches were conducted in databases and official websites including UpToDate, the National Guideline Clearinghouse (NGC), the Registered Nurses' Association of Ontario (RNAO), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, PubMed, Web of Science, CNKI, Wanfang Data, VIP, and Yimaitong. The search period covered from the inception of each database to December 31, 2024. The types of evidence included guideline, clinical decision, expert consensus, systematic review, Meta-analysis, and randomized controlled trial (RCT). Two researchers conducted the literature search, study selection, quality assessment and evidence extraction and synthesis independently.
Results:
A total of 16 articles were included, consisting of 1 guideline, 1 clinical decision, 2 expert consensuses, 4 systematic reviews, 3 Meta-analyses, and 5 RCTs. Nineteen pieces of evidence were ultimately categorized into 7 dimensions, including implementation team, intervention timing, training assessment, training methods, management of ICU-acquired weakness (ICU-AW), monitoring and safety, and outcome evaluation.
Conclusions:
This summary of best evidence for diaphragmatic function training in mechanically ventilated patients is scientifically rigorous and comprehensive, offering a valuable reference for guiding clinical practice.
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