[Molecular Mechanism of Neutrophils Driving the Progression of Lung Adenocarcinoma]

Lung cancer is one of the most prevalent and lethal malignant tumors worldwide, with lung adenocarcinoma (LUAD) being a major subtype. In recent years, research has revealed that the tumor microenvironment (TME) plays a crucial role in the development and progression of LUAD. Notably, the role of neutrophils has increasingly garnered attention. Studies have shown that neutrophils can differentiate into various phenotypes within the TME, exhibiting multiple pro-tumorigenic functions. Additionally, neutrophils can secrete neutrophil extracellular traps (NETs) in response to certain stimuli. Although NETs possess anti-tumor characteristics, an increasing number of studies have uncovered their multifaceted pro-tumor functions. This review describes the role of neutrophils in the initiation, development, and metastasis of LUAD, focusing on immunoregulation, cellular metabolism, genetics, and various molecular mechanisms.
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