Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

5.8K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.8K
Types of RNA01:20

Types of RNA

9.0K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
9.0K
Types of RNA01:23

Types of RNA

72.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.6K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Downregulation of ANKRD22 promotes ovarian cancer cell proliferation by enhancing the immunosuppressive capacity of M-MDSCs.

Cancer immunology, immunotherapy : CII·2026
Same author

Podocyte mPGES-2 Determines Renal Aging and Contributes to Senile Osteoporosis.

Aging cell·2026
Same author

Structural and dynamic insights into SPDT for phosphorus allocation in rice.

Science China. Life sciences·2026
Same author

STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy.

Cell reports·2026
Same author

The effect of autologous platelet rich plasma in the treatment of diabetic foot osteomyelitis patients.

Chinese journal of traumatology = Zhonghua chuang shang za zhi·2026
Same author

Hydroxylamine-accelerated cobalt redox cycling enables peroxymonosulfate activation for sustainable water remediation.

Environmental research·2026
Same journal

Integrated single-cell and spatial transcriptomics reveal stromal-immune-vascular crosstalk in patients with interstitial cystitis/bladder pain syndrome.

Experimental & molecular medicine·2026
Same journal

Establishing human immune system mice: application, opportunity, and challenges.

Experimental & molecular medicine·2026
Same journal

TRPC6 loss triggers mitochondrial dysfunction that drives white adipose tissue vulnerability to obesity and insulin resistance.

Experimental & molecular medicine·2026
Same journal

Restoring anisotropy after myocardial injury: strategies to align transplanted human induced pluripotent stem-cell-derived cardiomyocytes.

Experimental & molecular medicine·2026
Same journal

GM-CSF downregulates type I IFN responses in glioblastoma-associated monocytes.

Experimental & molecular medicine·2026
Same journal

Protein arginine methyltransferases coordinate mitochondrial stress adaptation and neuromuscular function.

Experimental & molecular medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

2.1K

Revisiting noncoding RNAs: emerging coding functions and their impact on skeletal muscle development.

Dandan Zhong1, Jian Wang1, Qi Li1

  • 1Guangxi Key Laboratory of Animal Breeding and Disease Control, College of Animal Science and Technology, Guangxi University, Nanning, China.

Experimental & Molecular Medicine
|January 7, 2026
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs (ncRNAs) can create peptides and proteins, impacting skeletal muscle development. This study reviews tools and findings on ncRNA-derived peptides, offering insights into muscle disorders.

More Related Videos

Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches
08:33

Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches

Published on: October 17, 2019

12.7K
Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
11:41

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity

Published on: June 16, 2022

2.4K

Related Experiment Videos

Last Updated: Jan 13, 2026

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

2.1K
Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches
08:33

Dissection of Drosophila melanogaster Flight Muscles for Omics Approaches

Published on: October 17, 2019

12.7K
Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
11:41

Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity

Published on: June 16, 2022

2.4K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Noncoding RNAs (ncRNAs) traditionally function as non-translating transcripts.
  • Emerging evidence shows ncRNAs can encode peptides/proteins via cryptic open reading frames.
  • These ncRNA-derived products have roles in skeletal muscle development.

Purpose of the Study:

  • To systematically evaluate computational tools for predicting ncRNA-encoded products.
  • To dissect the molecular mechanisms of ncRNA translation.
  • To synthesize the current knowledge of ncRNA-derived peptides/proteins in skeletal muscle.

Main Methods:

  • Computational tool and database evaluation for ncRNA product prediction.
  • Analysis of molecular mechanisms governing ncRNA translation.
  • Literature synthesis of identified ncRNA-derived peptides/proteins in skeletal muscle.

Main Results:

  • Identification and evaluation of computational resources for ncRNA-encoded peptide prediction.
  • Elucidation of mechanisms enabling translation of ncRNAs.
  • Compilation of known ncRNA-derived peptides/proteins in skeletal muscle across species.

Conclusions:

  • ncRNAs possess dual functionality as regulatory RNAs and peptide/protein precursors.
  • ncRNA-derived peptides play emerging roles in myogenesis.
  • This field offers potential novel therapeutic targets for muscle-related disorders.