Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimizing drug combinations to resurrect the potency of failed antibody therapy against emerging COVID-19 variants using IDentif.AI.

Frontiers in digital health·2026

Same author

Unique Digital Images as Incentives in Clinical Trials: A Digital Shift Toward Meaningful Participation.

Journal of medical Internet research·2026

Same author

Corrigendum to "Oculomics and AI: The eye as a biomarker for health span" [Asia-Pac J Ophthalmol 15 (1) (2026) 100282].

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2026

Same author

Oculomics and AI: The eye as a biomarker for health span.

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)·2026

Same author

The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1.

Oncogenesis·2026

Same author

Preliminary insights into artificial intelligence guided dosing in hypertension and diabetes: challenges and lessons learnt in a pilot feasibility study.

JAMIA open·2026

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

The functional imperative in high-grade glioma.

Laura Shih Hui Goh^1,2,3, Dexter Kai Hao Thng², Yvonne Li En Ang⁴

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Experimental & Molecular Medicine

|January 7, 2026

Summary

This summary is machine-generated.

Functional precision oncology (FPO) offers a personalized approach to treating high-grade gliomas by testing patient tumor cells against therapies. This method aims to overcome the limitations of current precision oncology strategies for improved patient outcomes.

More Related Videos

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

Related Experiment Videos

Last Updated: Jun 30, 2026

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

Area of Science:

Neuro-oncology
Cancer Biology
Translational Medicine

Background:

Precision oncology for high-grade gliomas has shown limited clinical success despite numerous trials.
Current strategies rely on static tumor markers, failing to capture complex biological responses to therapy.

Purpose of the Study:

To review historical and current high-grade glioma treatments.
To explore reasons for precision oncology's limited impact.
To introduce Functional Precision Oncology (FPO) as a complementary approach.

Main Methods:

Review of existing literature on high-grade glioma treatments.
Analysis of precision oncology trial outcomes.
Conceptual framework for integrating FPO into clinical practice.

Main Results:

Over 300 clinical trials targeting static markers have not significantly improved outcomes.
FPO dynamically tests patient-derived tumor cells against various agents for personalized treatment selection.
FPO addresses the limitations of static marker-driven approaches.

Conclusions:

Functional Precision Oncology (FPO) presents a promising strategy to enhance personalized treatment selection for high-grade gliomas.
Integrating FPO may overcome challenges in current precision oncology initiatives.
Practical considerations for implementing FPO in clinical decision-making are outlined.