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Related Experiment Video

Updated: Jun 16, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

Review: Systemic inflammation after stroke. Therapy and perspective.

Abuzan Mihaela^1,2, Andreea Cercel^3,4, Thorsten R Doeppner^1,3

¹Department of Neurology, University Medical Center Göttingen, 37075, Göttingen, Germany.

|January 7, 2026

Summary

This summary is machine-generated.

Systemic inflammation worsens stroke outcomes, especially in older adults and those with obesity. Research should target inflammation, explore aging-obesity links, and personalize treatments for better stroke recovery.

Keywords:

Aging Anti-inflammatory therapy Ischemic stroke Obesity Rehabilitation Systemic inflammation

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Last Updated: Jun 16, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

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Published on: February 12, 2016

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

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Published on: June 24, 2020

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Area of Science:

Neuroscience
Immunology
Gerontology

Background:

Systemic inflammation significantly impacts ischemic stroke severity and recovery.
Aging (inflammaging) and obesity exacerbate stroke-induced inflammation and neurological deficits.
The combined effects of aging and obesity create a significant barrier to stroke rehabilitation.

Purpose of the Study:

To highlight the need for targeted therapies modulating systemic inflammation post-stroke.
To emphasize elucidating molecular mechanisms linking aging, obesity, and inflammation.
To advocate for personalized treatment strategies considering individual risk factors.

Main Methods:

Review of existing literature on systemic inflammation, aging, obesity, and stroke.
Analysis of preclinical data on anti-inflammatory agents like minocycline.
Identification of key molecular pathways and immune cell phenotypes involved.

Main Results:

Aging and obesity amplify pro-inflammatory responses, worsening stroke outcomes.
Minocycline shows preclinical promise but requires clinical validation.
Adipokines and specific immune cell phenotypes are potential therapeutic targets.

Conclusions:

Targeted anti-inflammatory therapies and personalized medicine are crucial for improving post-stroke care.
Understanding the interplay of aging, obesity, and inflammation can reveal novel therapeutic targets.
Prioritizing prevention and identifying high-risk individuals is essential for vulnerable populations.