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Updated: Jan 13, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Performing Under Pressure: Maintenance of Donor Lung Pressure During Cabin Depressurization
John Eisenga1, Sigrid Ringenberg1, Magdy M El-Sayed Ahmed2
1Department of Thoracic Surgery, Baylor University Medical Center, Dallas, TX 75246, United States.
Introduction:
Maintenance of donor lung pressure is recommended to maintain inflation pressures of 12-15 mm Hg. This is particularly important given graft transportation in aircraft, due to the inevitable pressure changes.
Case:
We describe a case of a donor lung preservation system which maintained proper airway pressure during sudden cabin pressure loss requiring emergent landing.
Discussion:
The donor lungs were implanted without complication. Post-transplant course was notable for primary graft dysfunction (PGD) grade 1 at 24 hours, grade 2 at 48 hours, and grade 1 at 72 hours. At 3 months post-transplant, the patient has had no respiratory complications and has been noted to be doing well.
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