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Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
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Quantitative Sensory Testing Following Orthopedic Trauma: A Longitudinal Multisite Feasibility Study.

Rachel V Aaron1, Fenan S Rassu1, Kristin R Archer2,1,3

  • 1Department of Physical Medicine and Rehabilitation.

The Clinical Journal of Pain
|January 8, 2026
PubMed
Summary
This summary is machine-generated.

Quantitative sensory testing (QST) is feasible and acceptable for assessing pain after orthopedic trauma. Challenges like poor retention and analgesic use require solutions for future chronic pain research.

Keywords:
acute painchronic paininjurymusculoskeletalorthopaedicpostoperative painquantitative sensory testingtrauma

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Area of Science:

  • Orthopedic surgery outcomes
  • Pain medicine research
  • Clinical trial methodology

Background:

  • Orthopedic trauma is a leading cause of chronic pain and disability globally.
  • Quantitative sensory testing (QST) offers a standardized method to evaluate pain sensitivity post-injury.
  • Characterizing pain profiles may aid in predicting and managing chronic pain development.

Purpose of the Study:

  • To assess the feasibility and acceptability of a portable Quantitative Sensory Testing (QST) protocol.
  • To administer QST to adults six weeks after major orthopedic trauma and surgery.
  • To explore the relationship between QST measures and patient-reported pain.

Main Methods:

  • A cohort of 29 participants with major orthopedic trauma underwent QST at 6 weeks post-surgery.
  • QST included static measures, conditioned pain modulation, and mechanical temporal summation.
  • Feasibility, acceptability, and associations with clinical pain ratings were examined, with a 6-month follow-up survey planned.

Main Results:

  • Recruitment achieved 77% of eligible patients; QST procedures were feasible and well-tolerated.
  • No participants declined, withdrew due to procedures, or stopped testing due to discomfort.
  • Exploratory analysis showed a positive association between static QST and pain interference; however, 6-month retention was 57% and analgesic use was high (38%).

Conclusions:

  • Quantitative Sensory Testing (QST) demonstrated acceptability and partial feasibility in adults post-orthopedic trauma.
  • Key challenges identified include poor participant retention, high analgesic use, and logistical difficulties in testing injured areas.
  • Potential solutions are proposed to overcome these barriers in future research on chronic pain prediction.