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Updated: Jan 13, 2026

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
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Quantitative Sensory Testing Following Orthopedic Trauma: A Longitudinal Multisite Feasibility Study.

Rachel V Aaron1, Fenan S Rassu1, Kristin R Archer2,1,3

  • 1Department of Physical Medicine and Rehabilitation.

The Clinical Journal of Pain
|January 8, 2026
PubMed
Summary

Quantitative sensory testing (QST) is feasible and acceptable for assessing pain after orthopedic trauma. Challenges like poor retention and analgesic use require solutions for future chronic pain research.

Keywords:
acute painchronic paininjurymusculoskeletalorthopaedicpostoperative painquantitative sensory testingtrauma

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Area of Science:

  • Orthopedic surgery outcomes
  • Pain medicine research
  • Clinical trial methodology

Background:

  • Orthopedic trauma is a leading cause of chronic pain and disability globally.
  • Quantitative sensory testing (QST) offers a standardized method to evaluate pain sensitivity post-injury.
  • Characterizing pain profiles may aid in predicting and managing chronic pain development.

Purpose of the Study:

  • To assess the feasibility and acceptability of a portable Quantitative Sensory Testing (QST) protocol.
  • To administer QST to adults six weeks after major orthopedic trauma and surgery.
  • To explore the relationship between QST measures and patient-reported pain.

Main Methods:

  • A cohort of 29 participants with major orthopedic trauma underwent QST at 6 weeks post-surgery.
  • QST included static measures, conditioned pain modulation, and mechanical temporal summation.
  • Feasibility, acceptability, and associations with clinical pain ratings were examined, with a 6-month follow-up survey planned.

Main Results:

  • Recruitment achieved 77% of eligible patients; QST procedures were feasible and well-tolerated.
  • No participants declined, withdrew due to procedures, or stopped testing due to discomfort.
  • Exploratory analysis showed a positive association between static QST and pain interference; however, 6-month retention was 57% and analgesic use was high (38%).

Conclusions:

  • Quantitative Sensory Testing (QST) demonstrated acceptability and partial feasibility in adults post-orthopedic trauma.
  • Key challenges identified include poor participant retention, high analgesic use, and logistical difficulties in testing injured areas.
  • Potential solutions are proposed to overcome these barriers in future research on chronic pain prediction.