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Substance Use Disorders Affecting Sleep01:24

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: Jan 13, 2026

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Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders.

Luca Pavirani1,2,3, Bibi Aliya Seelarbokus1, Léa Marinelli2,4

  • 1Univ. Bordeaux, INCIA CNRS-UMR 5287, Bordeaux, France.

Addiction Biology
|January 8, 2026
PubMed
Summary

Vitamin D deficiency is highly prevalent in individuals with substance use disorders (SUDs). Low vitamin D levels were linked to increased craving for substances and food, suggesting potential benefits of supplementation during addiction treatment.

Keywords:
C‐reactive proteincalciumcraving for drugscraving for foodmicronutrientssubstance use disorders

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychiatry

Background:

  • Vitamin D influences dopaminergic pathways, implicating it in addiction.
  • The relationship between vitamin D and addiction symptoms in substance use disorder (SUD) patients requires further investigation.

Purpose of the Study:

  • To investigate differences in addiction, psychopathology, and biological markers based on vitamin D status in hospitalized SUD patients.

Main Methods:

  • 260 inpatients with SUDs had vitamin D, biomarkers, SUD severity, psychiatric disorders, cognitive function, and impulsivity assessed at admission.
  • Craving for substances and food, and negative affectivity were measured at admission and discharge.

Main Results:

  • A high prevalence of vitamin D deficiency (89.3%) was observed in the SUD patient group.
  • Vitamin D deficiency correlated with higher body weight, lower calcium, and increased craving for substances and food.
  • Multivariate analyses did not find significant links between vitamin D/calcium levels and craving at discharge.

Conclusions:

  • Confirms high vitamin D deficiency rates in SUD inpatients.
  • Highlights the need to assess vitamin D levels in SUD patients.
  • Suggests further research into vitamin D's role in relapse and potential benefits of supplementation during withdrawal.