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Related Experiment Video

Updated: Jan 13, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Clinical progress note: De-Labeling penicillin allergies.

Carter Groch¹, Stephy George², Daniel Giddings³

¹Methodist Richardson Medical Center, Department of Pharmacy, Richardson, Texas, USA.

Journal of Hospital Medicine

|January 8, 2026

Summary

This summary is machine-generated.

Many hospitalized adults with a penicillin allergy label can safely take penicillin, as most do not have a true allergy. Removing this label improves treatment, reduces costs, and lowers antibiotic resistance risks.

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Last Updated: Jan 13, 2026

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Area of Science:

Clinical Medicine
Infectious Diseases
Antimicrobial Stewardship

Background:

Approximately 15% of hospitalized adults report a penicillin allergy.
A significant proportion of these reported allergies are inaccurate, leading to suboptimal care.
Penicillin allergy labels are associated with increased healthcare costs, antibiotic resistance, and poorer patient outcomes.

Purpose of the Study:

To evaluate the impact of penicillin allergy de-labeling as an antimicrobial stewardship activity.
To assess the utility of the PEN-FAST scoring tool for identifying low-risk patients for penicillin re-challenge.

Main Methods:

Review of existing literature on penicillin allergy prevalence and outcomes.
Analysis of the misattribution of nonallergic rashes as hypersensitivity reactions.
Introduction of the PEN-FAST tool as a less cumbersome alternative to traditional allergy testing.

Main Results:

Around 90% of patients with a reported penicillin allergy tolerate penicillin upon re-challenge.
Misattribution of nonallergic rash or outgrowing the index reaction are common reasons for inaccurate allergy labels.
The PEN-FAST tool aids in identifying patients suitable for penicillin de-labeling.

Conclusions:

Removing inaccurate penicillin allergy labels is a crucial antimicrobial stewardship intervention.
The PEN-FAST tool offers a practical method for assessing penicillin allergy risk.
De-labeling penicillin allergies can lead to more effective antibiotic use and improved patient outcomes.