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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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RP11-Derived Long Non-Coding RNAs in Hepatocellular Carcinoma: Hidden Treasures in Plain Sight.

Se Ha Jang1,2, Hyung Seok Kim3, Jung Woo Eun1

  • 1Department of Gastroenterology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.

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RP11-derived long non-coding RNAs (lncRNAs) are key players in liver cancer. This review synthesizes their roles in hepatocellular carcinoma (HCC) progression, diagnosis, and potential as therapeutic targets.

Keywords:
Hepatocellular carcinomaRP11-derived lncRNAbiomarkerlong non-coding RNAtherapeutic target

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genomics

Background:

  • Hepatocellular carcinoma (HCC) is a major global health concern.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators in cancer.
  • RP11-derived lncRNAs, originating from bacterial artificial chromosome (BAC) clones, show significant functional diversity.

Purpose of the Study:

  • To systematically review current knowledge on RP11-derived lncRNAs in HCC.
  • To outline their genomic origins, molecular mechanisms, and biological significance.
  • To explore their potential as diagnostic/prognostic biomarkers and therapeutic targets.

Main Methods:

  • Systematic literature review and synthesis of existing research.
  • Analysis of genomic origins and molecular functions of RP11-derived lncRNAs.
  • Evaluation of their roles in HCC pathogenesis and clinical applications.

Main Results:

  • RP11-derived lncRNAs are implicated in metabolic reprogramming and microRNA network modulation in HCC.
  • They play significant roles in tumor progression.
  • These lncRNAs demonstrate diagnostic and prognostic value in both tissue and serum analyses.

Conclusions:

  • RP11-derived lncRNAs are crucial in HCC development and progression.
  • They hold promise as biomarkers for diagnosis and prognosis.
  • Further research can translate these findings into precision therapies for liver cancer.