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Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects
Ruiyang Li1,2,3,4,5,6, Yuezhou Wu1,2,3,4,5,6, Zhu'anzhen Zheng2,5,6
1Department of Orthopedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China.
Abstract:
Cancer and tissue regeneration pose great challenges to global health, as cancer treatment is impeded by tumor heterogeneity and therapy resistance, while regenerative medicine is constrained by donor shortages and difficulties in replicating native tissue structures. Organoids, as advanced three-dimensional multicellular structures derived from stem cells, have emerged as transformative tools in biomedical research. They recapitulate key aspects of native human tissue composition and functions, offering enhanced physiological relevance over traditional models. Therefore, this review aims to highlight the latest advancements in organoid technology within the fields of cancer research and regenerative medicine. We begin by discussing the fundamental aspects of organoid generation, characterization, and application. Furthermore, recent progress in both cancer-oriented and regeneration-focused organoids is summarized, with an emphasis on their applications in disease modeling, drug screening, mechanistic analysis, and precision medicine. Based on an extensive review of the literature, the current challenges and future directions in the development and application of organoid models are discussed. As organoid technology continues to evolve, it is anticipated that more high-quality studies will further advance medical science and foster innovation in personalized therapeutics.
Insights
Organoid technology offers advanced 3D models for cancer research and regenerative medicine. These stem cell-derived structures improve disease modeling, drug screening, and personalized therapeutics, overcoming limitations of traditional methods.
Area of Science:
- Biomedical Research
- Stem Cell Technology
- Tissue Engineering
Background:
- Cancer treatment faces challenges from tumor heterogeneity and therapy resistance.
- Regenerative medicine is limited by donor shortages and difficulties in replicating native tissue structures.
- Organoids, 3D stem cell-derived structures, offer enhanced physiological relevance for biomedical research.
Purpose of the Study:
- To review advancements in organoid technology for cancer research and regenerative medicine.
- To highlight organoid applications in disease modeling, drug screening, and personalized medicine.
- To discuss current challenges and future directions in organoid development and application.
Main Methods:
- Literature review of organoid generation, characterization, and application.
- Summarization of recent progress in cancer-oriented and regeneration-focused organoids.
- Analysis of organoid utility in disease modeling, drug screening, and mechanistic studies.
Main Results:
- Organoids recapitulate native tissue composition and functions, providing superior models.
- Organoid technology is advancing disease modeling, drug screening, and personalized medicine.
- Significant progress has been made in developing organoids for both cancer and regenerative applications.
Conclusions:
- Organoid technology is a transformative tool in cancer research and regenerative medicine.
- Continued evolution of organoid models promises to advance medical science and personalized therapeutics.
- High-quality organoid studies are crucial for future innovation in healthcare.
