PRAYAS: individual patient data meta-analysis database for Pooled Research and Analysis for Yielding Anemia-free...

Area of Science:

• Public Health
• Nutrition Science
• Epidemiology

Background:

• Anemia is a significant public health concern in India, affecting children, non-pregnant/non-lactating (NPNL) women, and pregnant women.
• Understanding anemia prevalence and contributing factors is crucial for effective public health interventions.

Purpose of the Study:

• To estimate anemia prevalence across different demographics in India using Individual Patient Data Meta-analysis (IPD-MA).
• To identify etiological factors, including micronutrient deficiencies, contributing to anemia.
• To evaluate the effectiveness of anemia prevention and treatment interventions and factors influencing non-response.

Main Methods:

• The PRAYAS IPD-MA database compiles data from 88 datasets (1994-2023) covering prevalence and intervention studies.
• Analysis includes over 319,721 participants for prevalence and 59,292 for interventions, stratified by age, region, and intervention type.
• Data includes demographic information, intervention details, and limited micronutrient status (e.g., ferritin, vitamin B12).

Main Results:

• The database includes a substantial number of participants for prevalence and intervention analyses, with a majority of datasets being randomized controlled trials.
• Geographical distribution shows a significant proportion of studies from northern India.
• Intervention data covers various treatments for pregnant women, NPNL women, and children, including iron supplementation and food-based approaches.

Conclusions:

• The PRAYAS database provides a comprehensive resource for understanding anemia in India.
• Findings will inform and refine strategies for the Anemia Mukt Bharat program.
• Evidence generated will support targeted interventions to reduce anemia burden across vulnerable populations.