Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

217
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
217
Computed Tomography01:10

Computed Tomography

8.0K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.0K
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

1.0K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.0K
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

235
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
235
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

165
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
165
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

280
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
280

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-Analysis: Redefining Liver Disease Risk in Heterozygous Alpha-1 Antitrypsin Deficiency.

Alimentary pharmacology & therapeutics·2026
Same author

Correction to: Deep learning-based motion correction: cardiac motion artifact and image quality improvements on chest CT.

Japanese journal of radiology·2026
Same author

Entropy for Prediction of MACEs in Myocarditis: A Cardiac MRI-based Biomarker of Myocardial Tissue Heterogeneity.

Radiology·2026
Same author

A multi-modal flow phantom for quantitative PET/Spectral CT.

bioRxiv : the preprint server for biology·2026
Same author

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Diagnostics (Basel, Switzerland)·2026
Same author

<i>Radiology: Cardiothoracic Imaging</i> Highlights 2025.

Radiology. Cardiothoracic imaging·2026

Related Experiment Video

Updated: Jan 13, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.8K

Obese patient imaging: improved dose efficiency with photon-counting CT.

Leening P Liu1, Kai Mei1, Shobhit Sharma2

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, PA.

Medrxiv : the Preprint Server for Health Sciences
|January 8, 2026
PubMed
Summary

Photon-counting CT (PCCT) offers superior dose efficiency over energy-integrating detector CT (EID-CT), significantly reducing noise and radiation dose. This advancement benefits imaging for larger patients and low-dose applications.

Keywords:
X-ray computed tomographydiagnostic imagingradiation dosage

More Related Videos

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.4K
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

16.5K

Related Experiment Videos

Last Updated: Jan 13, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.8K
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.4K
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

16.5K

Area of Science:

  • Medical Imaging
  • Radiology
  • CT Technology

Background:

  • Energy-integrating detector CT (EID-CT) is the standard for computed tomography.
  • Photon-counting CT (PCCT) utilizes cadmium-zinc-telluride (CZT) detectors, offering potential improvements in image quality and dose efficiency.
  • Evaluating dose efficiency across varying patient sizes is crucial for optimizing CT protocols.

Purpose of the Study:

  • To compare the dose efficiency of PCCT versus EID-CT.
  • To assess noise levels and potential dose reduction in different phantom sizes.
  • To investigate the impact of PCCT on non-Poisson noise.

Main Methods:

  • Utilized patient-specific 3D-printed pancreas and tissue-mimicking phantoms in extension rings simulating 50th to 95th percentile adult waist circumferences.
  • Scanned phantoms on both PCCT and EID-CT systems with varying dose levels (0.5-19.4 mGy).
  • Measured noise and quantified non-Poisson noise to evaluate dose efficiency and potential dose reduction at matched noise levels.

Main Results:

  • PCCT demonstrated superior noise reduction compared to EID-CT across all phantom sizes, with average reductions ranging from 22% to 28%.
  • Noise reduction with PCCT was more pronounced at lower doses and larger phantom sizes.
  • PCCT significantly reduced non-Poisson noise (p < 0.013) and enabled dose reductions of 33% (50th percentile) and 44% (95th percentile) at matched noise levels.

Conclusions:

  • PCCT exhibits significantly better dose efficiency than EID-CT across diverse phantom sizes.
  • The enhanced dose efficiency of PCCT allows for improved noise reduction and potential radiation dose reduction.
  • PCCT technology holds promise for optimizing imaging in obese patients and advancing low-dose CT applications.