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Related Experiment Video

Updated: Jan 13, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Navigating second-line therapy after immunotherapy in advanced HCC☆.

Arndt Vogel^1,2,3, Anna Saborowski¹, Lorenza Rimassa^4,5

¹Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

JHEP Reports : Innovation in Hepatology

|January 8, 2026

Summary

This summary is machine-generated.

Systemic treatments for hepatocellular carcinoma have advanced, but optimal sequencing after initial therapy remains unclear. This review examines current evidence and emerging strategies for second-line and later treatments.

Keywords:

Checkpoint inhibitor Hepatocellular carcinoma Intra-arterial therapies Local regional therapies Systemic therapy Tyrosine kinase inhibitor

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Area of Science:

Hepatobiliary cancers
Medical oncology
Clinical research

Background:

Systemic treatment options for hepatocellular carcinoma (HCC) have significantly improved survival outcomes.
Recent advances primarily focus on first-line therapies, creating challenges for subsequent treatment sequencing.
Limited head-to-head comparisons exist for second- and later-line HCC therapies.

Purpose of the Study:

To review current evidence for second-line and subsequent therapies in HCC.
To explore key considerations in optimizing treatment sequences for HCC.
To highlight emerging strategies in HCC management.

Main Methods:

Review of pivotal phase III trials and phase II studies.
Analysis of post hoc data and real-world evidence.
Consideration of clinical practice factors and ongoing research.

Main Results:

Significant improvements in survival and response have been observed with advanced systemic therapies.
Evidence for second-line HCC treatment is largely derived from non-comparative studies.
Treatment decisions involve integrating evidence with patient-specific factors.

Conclusions:

Optimal sequencing of therapies following HCC progression requires further investigation.
Emerging strategies like immunotherapy continuation and novel targeted agents show promise.
Refining the therapeutic landscape for HCC necessitates ongoing research and evidence generation.