Research Progress in Application of Multi-Omics Analysis in Alcoholic Liver Disease

Alcoholic liver disease(ALD) is chronic liver disease that significantly impacts global health,posing challenges in both diagnosis and treatment.Therefore,delving into the pathogenesis of ALD is of utmost importance.The advent of cutting-edge multi-omics has paved a new way for exploring ALD.Genomics,proteomics,transcriptomics,metabolomics,and gut microbiota investigations have shed light on the pathogenesis of ALD.Alterations in gene and protein expression,variations in metabolome,and the impact of gut microbiota are deemed pivotal in the progression of ALD.This paper comprehensively reviews the research progress of multi-omics in pinpointing prospective biomarkers and therapeutic targets in ALD,aiming to steer the forthcoming fundamental research and clinical practices for ALD.