Can we escape from top-priority ESKAPE pathogens?

Area of Science:

• Microbiology
• Infectious Diseases
• Public Health

Background:

• ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are critical-priority multidrug-resistant organisms.
• These bacteria are major contributors to the global antimicrobial resistance crisis, increasing morbidity, mortality, and healthcare costs.
• The ability of ESKAPE pathogens to evade conventional antibiotics complicates clinical management and infection control.

Conclusions:

• Coordinated and sustained interventions are necessary to tackle the global threat of ESKAPE pathogens.
• Progress in surveillance and novel therapies indicates a path forward.
• A balanced emphasis on prevention, surveillance, and therapeutic innovation is essential for the next decade.